EVERYTHING ABOUT SOK

The operate of SIK1 in tumorigenesis. SIK1 is actually a tumor suppressor gene, which performs a very important regulatory purpose in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and impacts most cancers mobile proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 may prom